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Disease activity return during natalizumab treatment interruption in patients with multiple sclerosis Neurol 76:1858-1865, OConnor, P.W.,et al, 2011 See this aricle in Pubmed Article Abstract Following interruption of natalizumab treatment, MS disease activity returned in a pattern that was consistent with known pharmacokinetic and pharmacodynamic properties of natalizumab, and did not show evidence of rebound.

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